Aging, Neurocognition, and Medication Adherence in HIV Infection

摘要: Objective To evaluate the hypothesis that poor adherence to highly active antiretroviral treatment (HAART) would be more strongly related cognitive impairment among older than younger HIV-seropositive adults. Setting and Participants A volunteer sample of 431 HIV-infected adult patients prescribed self-administered HAART was recruited from community agencies university-affiliated infectious disease clinics in Los Angeles area. Measurements Neurocognitive measures included tests attention, information processing speed, learning/memory, verbal fluency, motor functioning, executive functioning. Medication measured using microchip-embedded pill bottle caps (Medication Event Monitoring System) self-report. Latent/structural analysis techniques were used factor models cognition adherence. Results Mean rates higher (≥50 years) ( Conclusions Older HIV-positive individuals with neurocognitive or drug problems are at increased risk suboptimal medication. Likewise, adults may especially vulnerable immunological dysfunction under conditions These findings highlight importance optimizing medication evaluating neurocognition growing population patients.