Chemotherapy of canine leishmaniosis.
作者： Gad Baneth , Susan E Shaw
DOI: 10.1016/S0304-4017(02)00115-2
关键词:
摘要: Visceral leishmaniosis is a widespread and potentially fatal disease of dogs humans common in the Mediterranean region, Middle East, South America. Canine most frequently treated with drugs meglumine antimoniate, allopurinol, amphotericin B, or combination antimoniate allopurinol. Therapy currently used often achieves temporary clinical improvement changes immunologic parameters restoration ability to mount parasite-specific cell mediated responses decrease anti-leishmanial antibody titers. However, treatment usually does not prevent relapse eliminate parasite carriage. Due current lack an ultimate effective therapy for canine leishmaniosis, new drugs, delivery systems strategies are necessary achieve consistent parasitological cure infected dogs.
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