Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss.

摘要: In several studies reduced striatal dopamine D2/3 receptor (D2/3R) availability was reported in obese subjects compared to lean controls. Whether this is a reversible phenomenon remained uncertain. We previously determined the short-term effect of Roux-en-Y gastric bypass surgery (RYGB) on D2/3R (using [(123)I]IBZM SPECT) 20 morbidly women. Striatal lower controls at baseline, and unaltered after 6 weeks, despite significant weight loss. To determine whether long-term bariatric surgery-induced loss normalizes binding, we repeated binding measurements least 2 years RYGB 14 original cohort. addition, assessed changes body composition, eating behavior fasting plasma levels leptin, ghrelin, insulin glucose. Mean mass index declined from 46±7kg/m(2) 32±6kg/m(2), which accompanied by increase (p=0.031). significantly age-matched (BMI 22±2kg/m(2); p=0.01). Changes did not correlate with weight/fat, sensitivity, ghrelin or leptin levels. Scores questionnaires improved General Food Craving Questionnaire-State showed borderline correlation availability. These findings show that increases bariatric-surgery induced loss, suggesting obesity phenomenon.