摘要: Abstract A model for the myosin filament is presented. The based on: (1) staining pattern observed with anti-myosin in electron microscopy and its relation to M-line pseudo-H-zone; (2) presence of six radially distributed bridges between filaments M-line; (3) triangular profiles seen cross-sections thick through pseudo-H-zone. most significant features are that packing molecules along altered by tapered ends overlap pseudo-H-zone, ordered A-band positions restricted ability form M-bridges approximately 430-A repeat period generally can be accounted solely on basis superposition cross-bridges. has following important structural characteristics: aggregated parallel rows; pseudo-H-zone tail (L-meromyosin) everywhere else head tail; region there abutment same row; (4) ends, an one (approx. 430 A) each (5) 12 rows a cross-section 18 ends; (6) packed so profile obtained Nine surface three centrally located; (7) these make up sets four rows. In set two pairs. There stagger one-third pair
elsevier.com
sci-hub.se 参考文章(18)
D. Michael Young, Sylvia Himmelfarb, William F. Harrington, ON THE STRUCTURAL ASSEMBLY OF THE POLYPEPTIDE CHAINS OF HEAVY MEROMYOSIN. Journal of Biological Chemistry. ,vol. 240, pp. 2428- 2436 ,(1965) , 10.1016/S0021-9258(18)97341-2
Frank A. Pepe, The myosin filament Journal of Molecular Biology. ,vol. 27, pp. 227- 236 ,(1967) , 10.1016/0022-2836(67)90017-4
Frank A. Pepe, H. Finck, H. Holtzer, THE USE OF SPECIFIC ANTIBODY IN ELECTRON MICROSCOPY The Journal of Biophysical and Biochemical Cytology. ,vol. 11, pp. 533- 547 ,(1961) , 10.1083/JCB.11.3.533
H.E. Huxley, ELECTRON MICROSCOPE STUDIES ON THE STRUCTURE OF NATURAL AND SYNTHETIC PROTEIN FILAMENTS FROM STRIATED MUSCLE. Journal of Molecular Biology. ,vol. 7, pp. 281- 308 ,(1963) , 10.1016/S0022-2836(63)80008-X
R.A. Chaplain, R.T. Tregear, The mass of myosin per cross-bridge in insect fibrillar flight muscle Journal of Molecular Biology. ,vol. 21, pp. 275- 280 ,(1966) , 10.1016/0022-2836(66)90098-2
H. E. Huxley, The double array of filaments in cross-striated muscle. Journal of Cell Biology. ,vol. 3, pp. 631- 648 ,(1957) , 10.1083/JCB.3.5.631
Clara Franzini-armstrong, Keith R. Porter, SARCOLEMMAL INVAGINATIONS CONSTITUTING THE T SYSTEM IN FISH MUSCLE FIBERS. Journal of Cell Biology. ,vol. 22, pp. 675- 696 ,(1964) , 10.1083/JCB.22.3.675
C. Richard Zobel, F.D. Carlson, An electron microscopic investigation of myosin and some of its aggregates. Journal of Molecular Biology. ,vol. 7, pp. 78- 89 ,(1963) , 10.1016/S0022-2836(63)80020-0
Robert V. Rice, Conformation of individual macromolecular particles from myosin solutions Biochimica et Biophysica Acta. ,vol. 52, pp. 602- 604 ,(1961) , 10.1016/0006-3002(61)90427-9
G. F. ELLIOTT, J. LOWY, B. M. MILLMAN, X-ray diffraction from living striated muscle during contraction. Nature. ,vol. 206, pp. 1357- 1358 ,(1965) , 10.1038/2061357A0