Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery: a randomized, placebo-controlled trial.

摘要: Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have the potential to reduce acute kidney injury (AKI) after cardiac surgery through their pleiotropic properties. Here we studied preventive effect of atorvastatin on AKI valvular heart surgery. Two-hundred statin-naive patients were randomly allocated receive either statin or placebo. Atorvastatin was administered orally group according a dosage schedule (80 mg single dose evening prior surgery; 40 mg morning three further doses evenings postoperative days 0, 1, and 2). incidence assessed during first 48 hours basis Acute Kidney Injury Network criteria. The similar in control groups (21 vs. 26 %, respectively, p = 0.404). Biomarkers renal including plasma neutrophil gelatinase-associated lipocalin interleukin-18 also between groups. required significantly less norepinephrine vasopressin surgery, fewer vasopressin. There no significant differences outcomes. perioperative treatment not associated with lower improved clinical outcome undergoing (ClinicalTrials.gov NCT01909739).