Nicotinic Receptors Containing the α7 Subunit: A Model for Rational Drug Design
作者： G. Sharma , S. Vijayaraghavan
DOI: 10.2174/092986708786848703
关键词:
摘要: The neuronal nicotinic receptor has gained considerable recognition as a target, not just for combating drug addiction but also treating number of illnesses ranging from neurodegenerative diseases to psychotic disorders like schizophrenia. This led burgeoning field examining the at all levels. A class receptors that contains alpha7 gene product, apparently homomer, illustrates this multidisciplinary approach. Here, we review recent progress in our understanding based on data molecular, structural, physiological and patho-physiological studies. These studies have set stage rational design combat central nervous system. exemplify cautious approach needed developing CNS therapies importance physiology tempering design.
eurekaselect.com参考文章(157)
Normalization of Auditory Physiology by Cigarette Smoking in Schizophrenic Patients American Journal of Psychiatry. ,vol. 150, pp. 1856- 1861 ,(1993) , 10.1176/AJP.150.12.1856
Katjuša Brejc, Willem J. van Dijk, August B. Smit, Titia K. Sixma, The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor. Novartis Foundation symposium. ,vol. 245, pp. 22- 32 ,(2002) , 10.1002/0470868759.CH3
Fu-Ming Zhou, Yong Liang, John A. Dani, Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Nature Neuroscience. ,vol. 4, pp. 1224- 1229 ,(2001) , 10.1038/NN769
R. Douglas Shytle, Takashi Mori, Kirk Townsend, Martina Vendrame, Nan Sun, Jin Zeng, Jared Ehrhart, Archie A. Silver, Paul R. Sanberg, Jun Tan, Cholinergic modulation of microglial activation via alpha-7 nicotinic receptors Journal of Neurochemistry. ,vol. 89, pp. 337- 343 ,(2004) , 10.1046/J.1471-4159.2004.02347.X
Federico A. Dajas-Bailador, Adrian J. Mogg, Susan Wonnacott, Intracellular Ca2+ signals evoked by stimulation of nicotinic acetylcholine receptors in SH-SY5Y cells: contribution of voltage-operated Ca2+ channels and Ca2+ stores Journal of Neurochemistry. ,vol. 81, pp. 606- 614 ,(2002) , 10.1046/J.1471-4159.2002.00846.X
Kelly T Dineley, Marcus Westerman, Duy Bui, Karen Bell, Karen Hsiao Ashe, J David Sweatt, None, β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In Vitro and In Vivo Mechanisms Related to Alzheimer's Disease The Journal of Neuroscience. ,vol. 21, pp. 4125- 4133 ,(2001) , 10.1523/JNEUROSCI.21-12-04125.2001
Christopher Heeschen, James J. Jang, Michael Weis, Anjali Pathak, Shuichiro Kaji, Robert S. Hu, Philip S. Tsao, Frances L. Johnson, John P. Cooke, Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis Nature Medicine. ,vol. 7, pp. 833- 839 ,(2001) , 10.1038/89961
Jingming Zhang, Darwin K. Berg, Reversible inhibition of GABAA receptors by α7-containing nicotinic receptors on the vertebrate postsynaptic neurons The Journal of Physiology. ,vol. 579, pp. 753- 763 ,(2007) , 10.1113/JPHYSIOL.2006.124578
KatjuS̆a Brejc, Willem J. van Dijk, Remco V. Klaassen, Mascha Schuurmans, John van der Oost, August B. Smit, Titia K. Sixma, Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors Nature. ,vol. 411, pp. 269- 276 ,(2001) , 10.1038/35077011
K.-I. Nunoya, Y. Funae, Y. Kuroiwa, T. Yokoi, K. Nagashima, T. Yamamoto, T. Kamataki, K. Inoue, N. Shimada, M. Nakajima, Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metabolism and Disposition. ,vol. 24, pp. 1212- 1217 ,(1996)