Novel Therapeutic Approaches

摘要: During the latter part of twentieth century, substantial improvements were made in treatment childhood cancers. Fifty years ago, most pediatric cancers fatal. Today, however, more than 75% patients with cancer survive disease. Most advances have been achieved through extensive research and well-designed clinical trials. Investigators continue to explore novel therapies goals providing salvage whose disease does not respond current improving efficacy safety frontline regimens. Recent fields genetics, immunology, molecular biology led a better understanding cancers, which turn has rational design drugs based on thorough targets or inside malignant cells. Such an approach aims further improve cure rates reduce toxicity. This chapter describes available at M. D. Anderson Cancer Center. We describe difficulties conducting innovative children as well how multidisciplinary interactions help quickly safely benefit from therapies, including stem cell transplantation for leukemia, lymphoma, other solid tumors.