Type IV secretion system of Brucella spp. and its effectors.
作者： Yuehua Ke , Yufei Wang , Wengfeng Li , Zeliang Chen
关键词:
摘要: Brucella spp. are intracellular bacterial pathogens that cause infection in domestic and wild animals. They often used as model organisms to study infections. VirB T4SS is a key virulence factor plays important roles mediating survival manipulating host immune response infection. In this review, we discuss the of 15 effectors proposed be crucial for pathogenesis. regulates inflammation manipulates vesicle trafficking inside cells. also inhibition during Here, list molecular events life cycle potentially targeted by effectors. Elucidating functions these will help clarify role Furthermore, studying secreted might provide insights into mechanisms bacteria hijack signaling pathways aid development better vaccines therapies against brucellosis.
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