Prognostic value of biological markers in neuroblastoma: proposal for a methodology of analysis

摘要: The prognosis of pediatric neuroblastoma depends both on clinical presentation and certain cellular molecular characteristics. At the present time, two hypotheses can be drawn to explain biological heterogeneity. In first hypothesis, progresses from early late stages through a classical multistep process linked an accumulation abnormalities. second represents heterogeneous group unrelated diseases, where most I II or stage IVS neuroblastomas rather considered as benign tumors, IV true malignant proliferation. To ascertain relevant factors for disease, it is uppermost important that all investigators agree criteria analysis when tissue available in screened unscreened populations. This paper reviews tools neuroblastoma, priority markers according reliability, feasibility, reproducibility procedure, conditions storage further these markers. standardized evaluation will allow, first, collect sufficient data multivariate prognostic and, second, better define putative links between various forms disease.