Derivation of insulin-producing beta-cells from human pluripotent stem cells.
作者： Jacqueline V. Schiesser , Suzanne J. Micallef , Susan Hawes , Andrew G. Elefanty , Edouard G. Stanley
关键词:
摘要: Human embryonic stem cells have been advanced as a source of insulin-producing that could potentially replace cadaveric-derived islets in the treatment type 1 diabetes. To this end, protocols developed promote formation pancreatic progenitors and endocrine from human pluripotent cells, encompassing both induced cells. In review, we examine these methods place them context developmental embryological studies upon which they are based. particular, outline stepwise differentiation towards definitive endoderm, lineages emergence functional beta-cells. doing so, identify key factors common to many such discuss proposed action cellular ongoing development. We also compare strategies entail transplantation progenitor populations with those seek develop fully hormone expressing vitro. Overall, our survey literature highlights significant progress already made field identifies remaining deficiencies developing cell based for
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