Recurrent Respiratory Papillomatosis (RRP): Enriched HLA DQw3 Phenotype and Decreased Class I MHC Expression

摘要: Human papillomavirus (HPV) infection of the upper respiratory tract and larynx can cause recurrent, life-threatening disease in both adults children 1. Type 6 11 HPV are most frequent causes this 2,3. Latency is common benign outcome acute 6. However, some infected patients have a chronic course requiring many operative procedures to maintain patent airway. The immunologic response(s) that should prevent recurrent papilloma (RRP) development not well characterized. We recently identified restricted expression immune response genes by with RRP. This observation indicates T-cell dysregulation may predispose susceptible individuals develop Little understood about regulation cellular responses HPV. These show strong humoral. non-MHC 4,13, yet fail reactivation.