In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans

摘要: Human CD317 is an intrinsic immunity factor that restricts the release of enveloped viruses, including major pathogens HIV and Lassa virus, from infected cells in culture. Its importance for infection control humans unclear, due part to its incompletely defined vivo expression pattern. also has been proposed as a selective target immunotherapy multiple myeloma. To provide framework studies biological functions, regulation, therapeutic potential CD317, we performed microarray-based profiling 468 tissue samples 25 healthy organs more than 210 patients. We found protein was expressed varying degrees all tested detected number specialized cell types, hepatocytes, pneumocytes, ducts salivary glands, pancreas kidney, Paneth cells, epithelia, Leydig plasma bone marrow stromal monocytes, vascular endothelium. Although many these types are targets pathogenic restriction by or virus-encoded antagonists documented only some them. Limited type-dependent coexpression with IFN biomarker MxA lack responsive stimulation organ explants suggest interferons may partially regulate CD317. This sheds light on biology species-specificity identifies thus far unknown interaction sites viruses this factor, refutes concept restricted constitutive primary inducibility. CD317's widespread calls into question suitability immunotherapy.