Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response.
作者： Chin‐Hsiu Liu , Chung‐Tei Chou , Chen‐Hung Chen , Chun‐Hsiung Chen , Shii‐Yi Yang
DOI: 10.1002/KJM2.12184
关键词:
摘要: Although human leucocyte antigen (HLA)-B27 is strongly associated with ankylosing spondylitis (AS), the association of unfolded protein response (UPR) induced by HLA-B27 misfolding in AS remains controversial. Since dendritic cells (DCs) are crucial induction HLA-B27-transgenic rats, and plasmacytoid DCs (pDCs) belong to one type DCs, we here aim study relevance pDCs UPR AS. Peripheral were isolated from 27 HLA-B27(+) patients 37 controls. The bone marrow (BM) synovium inflamed hips controls obtained. We found a significantly higher frequency peripheral blood, BM, or hips, which enhanced expression pDC trafficking molecules, CCR6 CCL20 patients. Functional analysis further revealed that several inflammatory cytokines, including TNFα, IL-6, IL-23, secreted increased as compared those Remarkably, kinase RNA-like endoplasmic reticulum (PERK) pathway was up-regulated Notably, PERK inhibitor treatment inhibited cytokine production Further, extent activation disease severity Our data uncover aberrant distribution function not only contributes pDCs, but also activity
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