Non-reducible cyclic, and azaphenylalanyl6 analogues of somatostatin
作者： B.H. Hirst , J.D. Reed , B. Shaw , C.F. Hayward , J.S. Morley
DOI: 10.1016/0014-2999(80)90387-8
关键词:
摘要: Abstract Seven new analogues of somatostatin are described, along with the effects these on pentagastrin-stimulated gastric acid and pepsin secretion in conscious cats. Replacement cystine disulphide bridge an amide bridge, or without deletion N-terminal dipeptide, resulted approximately 20% potency somatostatin. Simultaneous omission Lys 4 amide-bridged reduced activity peptides to 5% Substitution Phe 6 analogue azaphenylalanyl no detectable activity. The results illustrate possible importance basic side-chain for lack demonstrate extreme orientation somatostatin, possibly binding receptors.
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