Original Article Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium

摘要: * Equal contributors. Received April 2, 2014; Accepted May 25, Epub 15, Published June 1, 2014 Abstract: Matrix metalloproteinase (MMP)-2 and MMP-9, two important members of the matrix family, have been shown critical contributions in intra-tumor angiogenesis invasion tumor progression, they might also play roles as well pannus formation rheumatoid arthritis (RA). In present study, we used immunohistochemistry, immunofluorescence staining con-focal scanning methods to characterize immunolocalization MMP-2 MMP-9 RA synovium tissues. Our results showed that both immunostaining could be found synoviocytes vascular endothelial cells. Moreover, our infiltrating CD14 + monocytes CD68 macrophages, macrophages tissues, while weak or negative these MMPs CD20 B cells CD3 T synovium. Thus, finding suggests expressed by certain immune role importantly progression.