Caspase activity sows the seeds of neuronal death.
作者： Junying Yuan , Bruce A. Yankner
DOI: 10.1038/10037
关键词:
摘要: Caspases, proteases involved in programmed cell death, may have a role Alzheimer’s and Huntington’s diseases. Localized caspase activation apoptosis be linked to the initiation of such chronic neurodegenerative
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Mark P. Mattson, Jeffrey N. Keller, James G. Begley, Evidence for synaptic apoptosis. Experimental Neurology. ,vol. 153, pp. 35- 48 ,(1998) , 10.1006/EXNR.1998.6863
X. Cai, T. Golde, S. Younkin, Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science. ,vol. 259, pp. 514- 516 ,(1993) , 10.1126/SCIENCE.8424174
M. Citron, C. Vigo-Pelfrey, D. B. Teplow, C. Miller, D. Schenk, J. Johnston, B. Winblad, N. Venizelos, L. Lannfelt, D. J. Selkoe, Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 91, pp. 11993- 11997 ,(1994) , 10.1073/PNAS.91.25.11993
Henning R. Stennicke, Quinn L. Deveraux, Eric W. Humke, John C. Reed, Vishva M. Dixit, Guy S. Salvesen, Caspase-9 Can Be Activated without Proteolytic Processing Journal of Biological Chemistry. ,vol. 274, pp. 8359- 8362 ,(1999) , 10.1074/JBC.274.13.8359
Kathryn J. Ivins, Elizabeth T.N. Bui, Carl W. Cotman, Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis. Neurobiology of Disease. ,vol. 5, pp. 365- 378 ,(1998) , 10.1006/NBDI.1998.0228
Y.P. Goldberg, D.W. Nicholson, D.M. Rasper, M.A. Kalchman, H.B. Koide, R.K. Graham, M. Bromm, P. Kazemi-Esfarjani, N.A. Thornberry, J.P. Vaillancourt, M.R. Hayden, Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nature Genetics. ,vol. 13, pp. 442- 449 ,(1996) , 10.1038/NG0896-442
Bruce A. Yankner, Mechanisms of Neuronal Degeneration in Alzheimer's Disease Neuron. ,vol. 16, pp. 921- 932 ,(1996) , 10.1016/S0896-6273(00)80115-4
François G. Gervais, Daigen Xu, George S. Robertson, John P. Vaillancourt, Yanxia Zhu, JingQi Huang, Andréa LeBlanc, David Smith, Michael Rigby, Mark S. Shearman, Earl E. Clarke, Hui Zheng, Leonardus H.T. Van Der Ploeg, Salvatore C. Ruffolo, Nancy A. Thornberry, Steve Xanthoudakis, Robert J. Zamboni, Sophie Roy, Donald W. Nicholson, Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation Cell. ,vol. 97, pp. 395- 406 ,(1999) , 10.1016/S0092-8674(00)80748-5
Joaquín Jordán, María F. Galindo, Richard J. Miller, Role of Calpain‐ and Interleukin‐1β Converting Enzyme‐Like Proteases in the β‐Amyloid‐Induced Death of Rat Hippocampal Neurons in Culture Journal of Neurochemistry. ,vol. 68, pp. 1612- 1621 ,(2002) , 10.1046/J.1471-4159.1997.68041612.X
Ivelisse Sánchez, Chi-Jie Xu, Peter Juo, Akira Kakizaka, John Blenis, Junying Yuan, Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats Neuron. ,vol. 22, pp. 623- 633 ,(1999) , 10.1016/S0896-6273(00)80716-3