P18-02. Peptide pulsed dendritic cells allows for induction of polyfunctional CD4+ T cell responses and help CD8+ T cell targeting subdominant CTL epitopes

摘要: Methods In a phase I/II therapeutic HIV-1 vaccine trial 12 treatment naive infected Danish individuals received 1 × 10e7 autologous monocyte derived dendritic cells s.c. (week 0, 2, 4 and 8) pulsed with 10 different peptides, 7 CTL epitopes from conserved regions of two one universal T helper epitope. Novel cell responses were evaluated by intracellular cytokine staining for IFN-γ, TNF-α IL-2.