No association between 25-hydroxyvitamin D and mammographic density.

摘要: There is increasing evidence that vitamin D may protect against breast cancer. Some studies have suggested dietary and supplemental associated with reduced mammographic density, which highly cancer risk, although this not entirely consistent. We investigated a possible association between circulating 25-hydroxyvitamin (25OHD), the best indicator of status, quantitative density in Minnesota Breast Cancer Family Study. Mean values (both percent area densities) levels 25OHD were compared across categories covariates using ANOVA. Models adjusted for age body mass index, as well other covariates, also stratified by calcium intake, menopause, season. Serum, questionnaire data available from 487 women [133 premenopausal 354 postmenopausal; mean age, 56.4 years (range, 27-85 years)] without cancer, 73%, blood was drawn within 1 year their mammogram. No found an either or total dense area. no any when season sample (winter summer) menopause. However, both lowest among those highest quartile intake above median. Unlike some previous reports, does seem to be related cohort. (Cancer Epidemiol Biomarkers Prev 2006;15(10):1988–92)