Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?
作者： Kuan-Teh Jeang
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摘要: The mechanism of HTLV-1 transformation cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known be required initiate transformation. Emerging evidence suggests that needed maintain transformed ATL phenotype. Recent studies have shown show deregulated expression cellular microRNAs (miRNAs). Here we discuss possibility early are Tax-oncogeneaddicted while late oncogenic microRNA (oncomiR) – addicted. potential utility interrupting oncomiR addiction as a cancer treatment broached.
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core.ac.uk 参考文章(33)
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