Synthesis, spectroscopic characterization, X-ray crystal structure and biological activities of homo- and heterobimetallic complexes with potassium-1-dithiocarboxylatopiperidine-4-carboxylate

摘要: Abstract Six homobimetallic organotin(IV) carboxylates dithiocarboxylates of the general formula R2(Cl)SnSSCLCOOSn(Cl)R2 (R = Me: 1; n-Bu: 2; Ph: 3)/R3SnSSCLCOOSnR3 4; 5; 6), a trinucleartin(IV) derivative [Ph2(Cl)SnSSCLCOO]2SnPh2 (7), three heterobimetallic (Sn, Pd) products type Cl2PdSSCLCOOSnR3 8; Bu: 9; 10) and palladium complex KOOCLCSSPdSSCLCOOK (11) were synthesized from potassium 1-dithiocarboxylatopiperidine-4-carboxylate (KSSCLCOOK) insitu. The structures complexes verified by spectroscopic techniques (FT-IR, UV–Visible, 1H NMR, 13C EI-MS/ESI) TGA. FT-IR data indicated bidentate binding mode carboxylate/dithiocarbamate group, with tetra penta-coordinated arrangements around Pd(II) Sn(IV) centers in solid state. In solution state, trigonal bipyramidal environment square planar geometry was justified NMR (1H 13C) UV–Vis spectroscopies. heteronuclear (8–10), ligand develops linkage through oxygen sulfur donor sites to Pd(II), respectively. mass fragmentation thermal degradation patterns excellently agreed molecular composition products. Single crystal XRD analysis 6 demonstrated that bonded tin(IV) lies between tetrahedral bipyramidal, while distorted arrangement for Sn(IV). exhibited antimicrobial activities against various strains bacteria fungi disc diffusion method their minimal inhibitory concentrations also found. nature coordinated metal played major role biological actions such complexes. While incorporation chiefly induces SS-DNA capacity ALPs inhibition complexes, coordination stimulates antibacterial antifungal potentials. sufficiently lower hemolytic as compared triton X-100 (positive control, 100% lysis) higher than PBS (negative 0% lysis).