Nutritional Programming of Immune Defense Against Infections in Early Life

摘要: Early-life programming is becoming an established concept stating that the environment during early development affects health and disease in adulthood, probably via epigenetic mechanisms. Accumulating evidence suggests nutrition pregnancy postnatal life one of most important environmental cues programs emerging organ systems offspring. The immune system may be particularly vulnerable. infants actively downregulated therefore first few months represent a period heightened susceptibility to infection. After birth, there age-dependent maturation layered manner. Exposure microbial components suggested play role process. This book chapter outlines early-life function, focusing on defenses against Food or nutrient deprivation as well overconsumption lead reduced responsiveness, increased inflammatory status which results ineffective responses infections. Nutritional intervention using prebiotics, probiotics, long-chain polyunsaturated fatty acids (LCPUFAs) has been provided support optimal hence provide better defense