Incident Type 2 Diabetes Mellitus in African American and White Adults

摘要: Context Although the excess prevalence of type 2 diabetes mellitus in African Americans is well established, few studies have compared incident American and white persons. Objectives To compare risk vs adults to identify explanatory factors for racial disparities. Design Prospective cohort study using baseline data collected from 1986 1989 ongoing Atherosclerosis Risk Communities (ARIC) Study, with 9 years follow-up. Setting Participants A total 2646 9461 aged 45 64 without at baseline, sampled 4 US communities. Main Outcome Measures Incident diabetes, ascertained by self-report physician diagnosis, use medications, or fasting glucose level least 7.0 mmol/L (126 mg/dL), among subjects presence potentially modifiable factors. Results Diabetes incidence per 1000 person-years was about 2.4-fold greater women (25.1 [95% confidence interval {CI}, 22.4-28.1] 10.4 CI, 9.4-11.4]) 1.5-fold men (23.4 19.9-27.2] 15.9 14.6-17.2]) than their counterparts (P<.001). proportional hazards regression models indicated that differences factors, particularly adiposity, accounted 47.8% but little men. Compared counterparts, had higher blood pressures before onset (diastolic pressure difference=5.6 mm Hg 8.4 men; P=.005). Conclusions Our indicate middle-aged are developing prior development diabetes. In women, almost 50% this might be related