Short-term 17β-estradiol decreases glucose Ra but not whole body metabolism during endurance exercise

摘要: The female sex hormone 17beta-estradiol (E(2)) has been shown to increase lipid and decrease carbohydrate utilization in animals. We administrated oral E(2) placebo (randomized, double blind, crossover) eight human male subjects for 8 days ( approximately 3 mg/day) measured respiratory variables, plasma substrates, hormones (E(2), testosterone, leptin, cortisol, insulin, catecholamines), substrate during 90 min of endurance exercise. [6,6-(2)H]glucose [1,1,2,3,3-(2)H]glycerol tracers were used calculate flux. administration increased serum (0.22 2.44 nmol/l, P < 0.05) decreased testosterone (19.4 11.5 concentrations, yet there no treatment effects on any the other hormones. Glucose rates appearance (R(a)) disappearance (R(d)) lower, glycerol R(a)-to-R(d) ratio was not affected by administration. O(2) uptake, CO(2) production, exchange E(2); however, a heart rate (P 0.05). Plasma lactate unaffected glucose significantly higher 0. 05) exercise after concluded that short-term R(a) R(d), maintained homeostasis, but had effect oxidation men.