Popeye proteins: muscle for the aging sinus node
作者： Bastiaan J. Boukens , Vincent M. Christoffels
DOI: 10.1172/JCI62588
关键词:
摘要: The electrical impulses that dictate the rhythm of heartbeat in normal situations and during exercise or stress are initiated by a small number sinus node pacemaker cells. Senescence dysfunction affects many people later life, causing physiologically inappropriate heart rates, but underlying mechanisms not well understood. In this issue JCI, Froese colleagues show deficiency either Popeye domain containing 1 (Popdc1) Popdc2 leads to under stressed conditions aged mice. mechanism reported underlie effects Popdc1/2 mice may cause stress-induced found individuals point new strategies for therapeutic intervention.
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