α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.
作者： Veronique G. VanderHorst , Tamara Samardzic , Clifford B. Saper , Matthew P. Anderson , Sukriti Nag
DOI: 10.1002/ANA.24430
关键词:
摘要: Urinary urgency and frequency are common in α-synucleinopathies such as Parkinson’s Disease, Lewy Body Dementia Multiple System Atrophy. These symptoms cannot be managed with dopamine therapy, their underlying pathophysiology is unclear. We show that individuals or Atrophy α-synuclein pathology accumulates the lateral collateral pathway, a region of sacral spinal dorsal horn important for relay pelvic visceral afferents. Deposition this may contribute to impaired micturition and/or constipation Disease other α–synucleinopathies.
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