Lymphopenia produced by polyethylene-32P strips applied to the rabbit appendix

摘要: Abstract Local, continuous irradiation of the rabbit appendix was produced by attaching to outer surface organ polyethylene strips impregnated with β-emitting isotope 32 P. This procedure reduced level small lymphocytes in blood 20–25% preoperative after 1 week. The labeling index a single injection 3 H-thymidine showed that there little or no reduction rate lymphocyte production attachment P strips. It is argued most likely mechanism lymphopenia destruction major population which recirculate continuously between and lymphoid tissue appendix. existence recirculation within regarded as additional evidence this serves peripheral function. Although marked maintained for 8 weeks longer, defect antibody formation skin graft rejection detected. Candida albicans infection joints progressed then regressed similar manner both groups, leaving chronic proliferative synovitis lasting at least 2–3 months.