The Significance of Nanoparticles in Medicine and Their Potential Application in Asthma

摘要: In an attempt to diagnose and treat highly complex often heterogeneous diseases, research aims utilise the modifiable properties of nano-sized particles. Properties such as size, shape, charge, hydrophobicity, surface chemistry may be altered in order facilitate promote targeted cellular uptake. Following first FDA-approved nanotherapeutic 1990, more than 40 have been marketed worldwide with multiple nano-based medicines currently development. Despite promising results, translation from pre-clinical experimentation a clinical setting has proven difficult. theory, nanoparticles are designed possess characteristics which address many challenges associated current practices, low toxicity, stability, biocompatibility, favourable distribution within target tissue, beneficial pharmacokinetic profiles. However, complexity identification ideal result is inherent any therapeutic research, especially one novel relatively progressive. The development for localised systemic delivery lung treatment respiratory disease also shows great potential. Due efficient clearance mechanisms lung, ability therapeutics successfully deposit tract major challenge. Yet correlation between exposure environmentally occupationally derived ultrafine (nano-sized) particles established. By confirming that capacity parts lower elicit response albeit toxic, epidemiological studies provide rationale pulmonary therapeutics. Although there little effort designing nanoparticle systems including asthma, involves nanocarriers clinically relevant asthma drugs antigen (for immunotherapy). With this, continued advancements understanding human coupled knowledge regarding interactions cell/tissue systems, required platform diagnostic research.