Precursors of the Blood Group NM Antigens Are Human Carcinoma-Associated

作者: Georg F. Springer , Parimal R. Desai , Satya M. Murthy , Edward F. Scanlon

DOI: 10.1016/B978-0-12-301302-6.50077-4

关键词:

摘要: Publisher Summary This chapter explains the relationship of precursors blood group NM antigens with human carcinoma. The Thomsen–Friedenreich (T) antigen is a direct precursor in biosynthesis N & M group. immediate T Tn antigen. Both do not occur reactive form healthy humans. specificities are associated breast carcinomata and also those gastrointestinal tract. In study described chapter, patients carcinoma persons without showed shrinking cell mediated immunity to but antigens. discusses way enhance immune system patents stage 2 3. It diagnostic therapeutic implications. presents percent absorption anti-blood m, n, agglutinins gland membrane-cytoplasm preparations carcinomata. group-specific immunodeterminant structures, which synthesized by sialyltransferases.

参考文章(6)
Georg F. Springer, Parimal R. Desai, Human blood-group MN and precursor specificities: structural and biological aspects. Carbohydrate Research. ,vol. 40, pp. 183- 192 ,(1975) , 10.1016/S0008-6215(00)82680-4
G. F. Springer, P. R. Desai, H. Schachter, S. Narasimhan, Enzymatic synthesis of human blood group M-, N- and T-specific structures Naturwissenschaften. ,vol. 63, pp. 488- 489 ,(1976) , 10.1007/BF00624592
G.F. Springer, P.R. Desai, H.J. Yang, M.S. Murthy, Carcinoma-associated blood group MN precursor antigens against which all humans possess antibodies Clinical Immunology and Immunopathology. ,vol. 7, pp. 426- 441 ,(1977) , 10.1016/0090-1229(77)90077-0
G. F. Springer, N. J. Ansell, INACTIVATION OF HUMAN ERYTHROCYTE AGGLUTINOGENS M AND N BY INFLUENZA VIRUSES AND RECEPTOR-DESTROYING ENZYME Proceedings of the National Academy of Sciences of the United States of America. ,vol. 44, pp. 182- 189 ,(1958) , 10.1073/PNAS.44.2.182