Activation of TRPV4 ion channel by physical stimuli and critical role for TRPV4 in organ-specific inflammation and itch

摘要: Provided are methods of treating and/or preventing dermatological disorders. reducing skin inflammation, pain, itch in a subject need thereof. The may include administering to the an effective amount TRPV4 inhibitor. Further provided compositions including inhibitor compound combination with carrier, vehicle, or diluent that is suitable for topical application. transgenic mouse whose genome includes deletions Trpv4 gene keratinocytes epidermis, wherein said knockout epidermis following keratinocyte-specific activation and expression site-specific recombination enzyme.