Spirooxindoles: reaction of 2,6-diaminopyrimidin-4(3H)-one and isatins

作者: Khosrow Jadidi , Ramin Ghahremanzadeh , Ayoob Bazgir

DOI: 10.1016/J.TET.2009.01.013

关键词:

摘要: Abstract A simple and efficient cyclocondensation reaction of 2,6-diaminopyrimidin-4(3H)-one isatins for the synthesis spiro[pyrimido[4,5-b]quinoline-5,5′-pyrrolo[2,3-d]pyrimidine] spiro[indoline-pyrido[2,3-d:6,5-d′]dipyrimidine] derivatives is reported.

参考文章(30)
S Joseph, J M Burke, Optimization of an anti-HIV hairpin ribozyme by in vitro selection. Journal of Biological Chemistry. ,vol. 268, pp. 24515- 24518 ,(1993) , 10.1016/S0021-9258(19)74492-5
Olga Bruno, Chiara Brullo, Silvia Schenone, Francesco Bondavalli, Angelo Ranise, Massimiliano Tognolini, Mariannina Impicciatore, Vigilio Ballabeni, Elisabetta Barocelli, Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4,3-d]pyrimidin-5-ones. Bioorganic & Medicinal Chemistry. ,vol. 14, pp. 121- 130 ,(2006) , 10.1016/J.BMC.2005.07.066
Shouming Wang, Adrian Folkes, Irina Chuckowree, Xiaoling Cockcroft, Sukhjit Sohal, Warren Miller, John Milton, Stephen P. Wren, Nigel Vicker, Paul Depledge, John Scott, Lyndsay Smith, Hazel Jones, Prakash Mistry, Richard Faint, Deanne Thompson, Simon Cocks, Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance. Journal of Medicinal Chemistry. ,vol. 47, pp. 1329- 1338 ,(2004) , 10.1021/JM031011G
Minoo Dabiri, Seyyedeh Cobra Azimi, Hamid Reza Khavasi, Ayoob Bazgir, A novel reaction of 6-amino-uracils and isatins Tetrahedron. ,vol. 64, pp. 7307- 7311 ,(2008) , 10.1016/J.TET.2008.05.063
Brett C. Bookser, Bheemarao G. Ugarkar, Michael C. Matelich, Robert H. Lemus, Matthew Allan, Megumi Tsuchiya, Masami Nakane, Atsushi Nagahisa, James B. Wiesner, Mark D. Erion, Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds Journal of Medicinal Chemistry. ,vol. 48, pp. 7808- 7820 ,(2005) , 10.1021/JM050394A
D. Martin James, Holly B. Kunze, D. John Faulkner, Two new brominated tyrosine derivatives from the sponge Druinella (= Psammaplysilla) purpurea. Journal of Natural Products. ,vol. 54, pp. 1137- 1140 ,(1991) , 10.1021/NP50076A040
Jun'ichi Kobayashi, Masashi Tsuda, Kaori Agemi, Hideyuki Shigemori, Masami Ishibashi, Takuma Sasaki, Yuzuru Mikami, Purealidins B and C, new bromotyrosine alkaloids from the okinawan marine sponge psammaplysilla purea Tetrahedron. ,vol. 47, pp. 6617- 6622 ,(1991) , 10.1016/S0040-4020(01)82314-0
David W. Robertson, Joseph H. Krushinski, G. Don Pollock, Harve Wilson, Raymond F. Kauffman, J. Scott Hayes, Dihydropyridazinone cardiotonics: synthesis and inotropic activity of 5'-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)spiro[cycloalkane- 1,3'-[3H]indol]-2'(1'H)-ones. Journal of Medicinal Chemistry. ,vol. 30, pp. 824- 829 ,(1987) , 10.1021/JM00388A014
Sarah R. Yong, Morwenna C. Williams, Stephen G. Pyne, Alison T. Ung, Brian W. Skelton, Allan H. White, Peter Turner, Synthesis of 2-azaspiro[4.4]nonan-1-ones via phosphine-catalysed [3+2]-cycloadditions Tetrahedron. ,vol. 61, pp. 8120- 8129 ,(2005) , 10.1016/J.TET.2005.06.050