Functional Lung Imaging during HFV in Preterm Rabbits

摘要: Although high frequency ventilation (HFV) is an effective mode of ventilation, there limited information available in regard to lung dynamics during HFV. To improve the knowledge function HFV we have developed a novel imaging and analysis technique. The technique can determine complex motion vivo with temporal resolution capable observing dynamics. Using high-speed synchrotron based phase contrast X-ray cross-correlation analysis, this method recording data more than 60 independent regions across preterm rabbit excess 300 frames per second (fps). This utilised regional intra-breath mechanics pups Whilst ventilated at fixed pressures, each animal was frequencies 1, 3, 5 10 Hz. A 50% decrease delivered tidal volume measured Hz compared 1 Hz, yet higher 500% increase minute activity measured. Additionally, induced greater homogeneity expansion suggesting strategy potentially minimizes tissue damage improves gas mixing. development permits insight further research into may implications for improvement strategies used support severe pulmonary trauma disease.