Theoretical analysis of neural crest cell migration

摘要: The neural crest cells are embryonic stem that migrate throughout embryos and, at different target locations, give rise to the formation of a variety tissues and organs. directional migration is experimentally described using process referred as contact inhibition locomotion (CIL), by which redirect their movement upon contacts between cells. However, it unclear how alignment affected motility properties Here, we computationally model average time reach location functions dynamics interaction in an open domain with channel geometry. results indicate varying CIL transition takes place from random organized collective migration, where maximised minimised. This phase accelerated strengthened influx rate into through increasing density migrating further suggests more coordinated when large radius move fast narrow domain.