Plasma free cortisol and B-type natriuretic peptide in septic shock

摘要: Previous studies of patients with septic shock have independently demonstrated alterations in plasma concentrations B-type natriuretic peptide and free cortisol. data suggest that a reciprocal relationship might exist. However, the between these hormones is unclear. We sought to compare paired measurement both cortisol study patients. Twenty-one consecutive adult from tertiary level, multidisciplinary intensive care unit underwent blood collection within 72 hours developing shock. Mean ± SD Acute Physiology Chronic Health Evaluation III score was 80.1 23.8. Hospital mortality 29%. Log positive correlation log (r=0.55, P=0.019). also correlated (r=0.67, P <0.001) noradrenaline dose P=0.01). (P=0.001) (P=0.02) were independent predictors A model incorporating variables explained 68% variation (R-square=0.682). This demonstrates previously unappreciated b-type concentration.