Pick's Disease: A Clinical and Ultrastructural Study

摘要: Brain biopsy was performed on a 61-year-old woman with four-year history of progressive dementia. Light microscopy revealed typical amphophilic, argentophilic Pick bodies in cortical neurons, many which were ballooned and displayed central chromatolysis. A few senile plaques apparent the neuropil, but neurofibrillary tangles not found. The seen by electron to be made up 100 Angstrom filaments, ribosomes, vesicles, lipochrome, some 240 tubules. Inclusions sharply demarcated from remainder cytoplasm closely resembled chromatolysis axonal reaction. Therefore, it is proposed that cells are result retrograde or transsynaptic degeneration neuron aggregates whatever fibrillar material has can make. quite except they lacked twisted