Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile.

摘要: Objective To assess acute and chronic histopathological changes observed in a swine arteriovenous malformation model after endovascular delivery of Embolyx E (Micro Therapeutics Inc., San Clemente, CA) its organic solvent dimethyl sulfoxide (DMSO). develop standard techniques through microcatheters into rete mirabile (RMB). Methods Forty RMBs 22 were used to analyze angiographic histological superselective and/or Four (two for DMSO two study) as control specimens. Angiographic evaluations obtained 18 days, 1 month, 3 months, 6 months the procedure. Particular attention was paid presence focal or diffuse angionecrosis, arterial revascularization, perivascular inflammatory response. Results Staged continuous performed DMSO-compatible without untoward catheter "gluing." All subacute/chronic specimens embolized with showed no evidence recanalization. Twelve studies, all angionecrosis aggressive reaction. Subacute (total, n = 14) examinations mild response manifested by monocellular infiltration scattered foreign body giant cell In 9 14 subacute specimens, disruption elastica along embolic materials. Fourteen eight determine safety range injection. Two Rapid intra-arterial (0.5 ml/5-15 s, 6) caused vasospasm endothelial necrosis. Slow injection ml/30-120 8) minimum vasospasm, minimal adventitial response, clinical complications. Conclusion E, an occlusive nonadhesive agent, is capable producing permanent occlusion RMB development intra- The slow produces angiographic, pathological, changes. A fast causes necrosis severe wall. This material seems have appropriate biochemical, anatomic, characteristics be treatment cerebral malformations vascular cranial base tumors.