Dehydroabietic Acid Is a Novel Survivin Inhibitor for Gastric Cancer.

摘要: Gastric cancer is a malignant tumor with high incidence and mortality rate worldwide. Nevertheless, anticancer drugs that can be used for gastric treatment are limited. Therefore, it important to develop targeted the of cancer. Dehydroabietic acid (DAA) diterpene found in tree pine. Previous studies have demonstrated DAA inhibits cell proliferation by inducing apoptosis. However, we did not know how cells through In this study, attempted identify genes induce cycle arrest death, as well those which altered treatment. DAA-regulated were screened using RNA-Seq differentially expressed (DEGs) analysis AGS cells. revealed expression survivin, an apoptosis inhibitor, was significantly reduced We also confirmed decreased survivin RT-PCR Western blotting analysis. addition, ability inhibit compared YM-155, known inhibitor. stronger inhibitory effect comparison YM-155. caused increase cleaved caspase-3, apoptosis-activating protein. conclusion, potential agent expression.