Marked Potentiation of Activity of β-Lactams against Methicillin-Resistant Staphylococcus aureus by Corilagin
作者： Masato Shimizu , Sumiko Shiota , Tohru Mizushima , Hideyuki Ito , Tsutomu Hatano
DOI: 10.1128/AAC.45.11.3198-3201.2001
关键词:
摘要: We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. isolated effective compound identified it corilagin. Corilagin various β-lactams by 100- to 2,000-fold but not other antimicrobial agents tested. The effect corilagin was synergistic. showed a bactericidal action when added growth medium in combination with oxacillin.
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