Future potential of glycomics in microbiology and infectious diseases

作者: Mark von Itzstein , Anthony P. Moran

DOI: 10.1016/B978-0-12-374546-0.00050-X

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摘要: Publisher Summary This chapter provides a brief overview of some highlights from number the most recent technological developments that have made study carbohydrates and carbohydrate-recognizing proteins in infectious disease biology more accessible to nonexpert. Glycomics, as systematic carbohydrate polymers oligosaccharides, seeks interpret what can be called third molecular language cells. As play pivotal roles infection, pathogen survival, propagation, microbial glycomics is poised revolutionize both antimicrobial vaccine drug discovery. In time when resistance clinically significant bacteria fungi has occurred, where only limited therapy available for other pathogens such viruses parasites, new discovery therapeutic strategies are required. The exploration role been given boost through advances, analytical synthetic chemistry, reviewed this overview. Furthermore, future outlook development summarized.

参考文章(40)
Hildegard Geyer, Rudolf Geyer, Strategies for analysis of glycoprotein glycosylation. Biochimica et Biophysica Acta. ,vol. 1764, pp. 1853- 1869 ,(2006) , 10.1016/J.BBAPAP.2006.10.007
Mark von Itzstein, Magdalena Plebanski, Brian M. Cooke, Ross L. Coppel, Hot, sweet and sticky: the glycobiology of Plasmodium falciparum Trends in Parasitology. ,vol. 24, pp. 210- 218 ,(2008) , 10.1016/J.PT.2008.02.007
Anthony P. Moran, Yuriy A. Knirel, Sof'ya N. Senchenkova, Göran Widmalm, Sean O. Hynes, Per-Erik Jansson, Phenotypic Variation in Molecular Mimicry betweenHelicobacter pylori Lipopolysaccharides and Human Gastric Epithelial Cell Surface Glycoforms ACID-INDUCED PHASE VARIATION IN LEWISXAND LEWISY EXPRESSION BY H. PYLORILIPOPOLYSACCHARIDES Journal of Biological Chemistry. ,vol. 277, pp. 5785- 5795 ,(2002) , 10.1074/JBC.M108574200
S HASLAM, S NORTH, A DELL, Mass spectrometric analysis of N- and O-glycosylation of tissues and cells. Current Opinion in Structural Biology. ,vol. 16, pp. 584- 591 ,(2006) , 10.1016/J.SBI.2006.08.006
F. Lehmann, E. Tiralongo, J. Tiralongo, Sialic acid-specific lectins: occurrence, specificity and function Cellular and Molecular Life Sciences. ,vol. 63, pp. 1331- 1354 ,(2006) , 10.1007/S00018-005-5589-Y
Thomas Haselhorst, Helen Blanchard, Martin Frank, Mark J. Kraschnefski, Milton J. Kiefel, Alex J. Szyczew, Jeffery C. Dyason, Fiona Fleming, Gavan Holloway, Barbara S. Coulson, Mark von Itzstein, STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core. Glycobiology. ,vol. 17, pp. 68- 81 ,(2007) , 10.1093/GLYCOB/CWL051
Jesus Angulo, Christoph Rademacher, Thorsten Biet, Andrew J. Benie, Astrid Blume, Hannelore Peters, Monica Palcic, Francisco Parra, Thomas Peters, NMR analysis of carbohydrate-protein interactions. Methods in Enzymology. ,vol. 416, pp. 12- 30 ,(2006) , 10.1016/S0076-6879(06)16002-4
Thomas Haselhorst, Jennifer C. Wilson, Robin J. Thomson, Sarah McAtamney, John G. Menting, Ross L. Coppel, Mark von Itzstein, Saturation transfer difference (STD) 1H‐NMR experiments and in silico docking experiments to probe the binding of N‐acetylneuraminic acid and derivatives to Vibrio cholerae sialidase Proteins. ,vol. 56, pp. 346- 353 ,(2004) , 10.1002/PROT.20143
Thomas Haselhorst, Jean-Michel Garcia, Tasneem Islam, Jimmy C. C. Lai, Faith J. Rose, John M. Nicholls, J. S. Malik Peiris, Mark von Itzstein, Avian Influenza H5‐Containing Virus‐Like Particles (VLPs): Host‐Cell Receptor Specificity by STD NMR Spectroscopy Angewandte Chemie. ,vol. 47, pp. 1910- 1912 ,(2008) , 10.1002/ANIE.200704872