Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging
作者： Yonghua Zhan , Sixiang Shi , Emily B. Ehlerding , Stephen A. Graves , Shreya Goel
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摘要: Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field biomedical imaging because their ability to create an enhanced signal MRI as novel potent T1 contrast agents. In this study, we present tumor vasculature-targeted mice using Mn3O4 NPs through conjugation anti-CD105 antibody TRC105 and radionuclide copper-64 (64Cu, t1/2: 12.7 h). The conjugated NPs, 64Cu-NOTA-Mn3O4@PEG-TRC105, exhibited sufficient stability vitro vivo. Serial positron emission tomography (PET) magnetic resonance (MRI) studies evaluated pharmacokinetics demonstrated targeting 64Cu-NOTA-Mn3O4@PEG-TRC105 4T1 murine breast tumors vivo, compared 64Cu-NOTA-Mn3O4@PEG. specificity for vascular marker CD105 was confirmed vitro, ex vivo experiments. Since desirable properties low toxicity, tumor-speci...
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