Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases, a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG)

作者: Joost Huiskens , Thomas M van Gulik , Krijn P van Lienden , Marc RW Engelbrecht , Gerrit A Meijer

DOI: 10.1186/S12885-015-1323-9

关键词:

摘要: Colorectal cancer patients with unresectable liver-only metastases may be cured after downsizing of by neoadjuvant systemic therapy. However, the optimal induction regimen has not been defined, and lack consensus on criteria for (un)resectability complicates interpretation published results.

参考文章(33)
Fotios Loupakis, Chiara Cremolini, Gianluca Masi, Sara Lonardi, Vittorina Zagonel, Patrizia Trenta, Gianluca Tomasello, Monica Ronzoni, Libero Ciuffreda, Alberto Zaniboni, Giuseppe Tonini, Angela Buonadonna, Chiara Valsuani, Silvana Chiara, Chiara Carlomagno, Corrado Boni, Lorenzo Marcucci, Luca Boni, Alfredo Falcone, FOLFOXIRI plus bevacizumab (bev) versus FOLFIRI plus bev as first-line treatment of metastatic colorectal cancer (MCRC): Results of the phase III randomized TRIBE trial. Journal of Clinical Oncology. ,vol. 31, pp. 336- 336 ,(2013) , 10.1200/JCO.2013.31.4_SUPPL.336
Volker Heinemann, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Ursula Vehling-Kaiser, Salah-Eddin Al-Batran, Tobias Heintges, Juergen Lerchenmueller, Christoph Kahl, Gernot Seipelt, Frank Kullmann, Martina Stauch, Werner Scheithauer, Joerg Hielscher, Michael Scholz, Sebastian Mueller, Britta Schaefer, Dominik Paul Modest, Andreas Jung, Sebastian Stintzing, Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS-wildtype metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3). Journal of Clinical Oncology. ,vol. 31, ,(2013) , 10.1200/JCO.2013.31.15_SUPPL.LBA3506
Alfredo Falcone, Chiara Cremolini, Gianluca Masi, Sara Lonardi, Vittorina Zagonel, Lisa Salvatore, Patrizia Trenta, Gianluca Tomasello, Monica Ronzoni, Libero Ciuffreda, Alberto Zaniboni, Giuseppe Tonini, Angela Buonadonna, Chiara Valsuani, Silvana Chiara, Chiara Carlomagno, Corrado Boni, Lorenzo Marcucci, Luca Boni, Fotios Loupakis, FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): Results of the phase III TRIBE trial by GONO group. Journal of Clinical Oncology. ,vol. 31, pp. 3505- 3505 ,(2013) , 10.1200/JCO.2013.31.15_SUPPL.3505
F Bertolini, N Malavasi, L Scarabelli, F Fiocchi, B Bagni, C Del Giovane, G Colucci, G E Gerunda, R Depenni, S Zironi, A Fontana, E Pettorelli, G Luppi, P F Conte, FOLFOX6 and bevacizumab in non-optimally resectable liver metastases from colorectal cancer British Journal of Cancer. ,vol. 104, pp. 1079- 1084 ,(2011) , 10.1038/BJC.2011.43
Jolien Tol, Iris D. Nagtegaal, Cornelis J.A. Punt, BRAF mutation in metastatic colorectal cancer. The New England Journal of Medicine. ,vol. 361, pp. 98- 99 ,(2009) , 10.1056/NEJMC0904160
Henry Bismuth, René Adam, Françis Lévi, Christian Farabos, Fabio Waechter, Denis Castaing, Pietro Majno, Luc Engerran, Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy. Annals of Surgery. ,vol. 224, pp. 509- 522 ,(1996) , 10.1097/00000658-199610000-00009
Ren?? Adam, Val??rie Delvart, G??rard Pascal, Adrian Valeanu, Denis Castaing, Daniel Azoulay, Sylvie Giacchetti, Bernard Paule, Francis Kunstlinger, Odile Gh??mard, Francis Levi, Henri Bismuth, Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival. Annals of Surgery. ,vol. 240, pp. 644- 658 ,(2004) , 10.1097/01.SLA.0000141198.92114.F6
Ren?? Adam, Gerard Pascal, Denis Castaing, Daniel Azoulay, Valerie Delvart, Bernard Paule, Francis Levi, Henri Bismuth, Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases? Annals of Surgery. ,vol. 240, pp. 1052- 1064 ,(2004) , 10.1097/01.SLA.0000145964.08365.01
J Souglakos, N Androulakis, K Syrigos, A Polyzos, N Ziras, A Athanasiadis, S Kakolyris, S Tsousis, Ch Kouroussis, L Vamvakas, A Kalykaki, G Samonis, D Mavroudis, V Georgoulias, FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer (MCC): a multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG) British Journal of Cancer. ,vol. 94, pp. 798- 805 ,(2006) , 10.1038/SJ.BJC.6603011
Miriam Koopman, Cornelis J.A. Punt, Chemotherapy, which drugs and when European Journal of Cancer. ,vol. 45, pp. 50- 56 ,(2009) , 10.1016/S0959-8049(09)70016-4