Clinical-Pathological Correlation of KRAS Mutation Status in Metastatic Colorectal Adenocarcinoma

摘要: Background: KRAS gene mutations play an important role in the carcinogenesis of colorectal tumors. However, studies that have assessed association between mutation status and disease characteristics report conflicting results. To assess status (mutated or wild-type) its association with clinical, epidemiological, histopathological features metastatic adenocarcinoma as well clinical outcomes. Methods: Cross-sectional descriptive study which histopathological data were collected from medical records 65 patients diagnosed colorectal at Clinical Oncology Service Teaching Hospital School Medicine Ribeirao Preto, University Sao Paulo (Hospital das Clinicas da Faculdade de Medicina Universidade Sao -HCFMRP-USP) 2005 2012 analyzed based on their status. Results: found 49.2% tumors, G/A (25.5%) Gly12Asp (34.37%) most frequent mutations. Among investigated (gender, ECOG (Eastern Cooperative Group), histology, degree cell differentiation, lymph node ratio, primary tumor site, staging, presence synchronous metastasis, lung liver metastasis), age less than years KRAS was statistically significant (P = 0.046). did not exhibit a correlation overall survival patients 0.078); however, cases exhibited shorter survival. In multivariate analysis, metastasis 0.03) 0.008) behaved independent factors poor prognosis relative to the patients. Conclusion: The prognostic value sample. Among older ( > old), wild-type more frequently observed compared to mutated KRAS. World J Oncol • 2013;4(4-5):179-187 doi: http://dx.doi.org/10.4021/wjon719w