Sleep apnea syndrome: a possible contributing factor to resistant.

摘要: STUDY OBJECTIVES There is evidence supporting an association between sleep apnea and hypertension. However, it not clear if interteres with the pharmacotherapy of To investigate this question, we studied relationship effectiveness anti-hypertensive treatment in reducing blood pressure, severity a large group apneic patients referred to disorders centre at St. Michael's Hospital University Toronto. DESIGN N/A. SETTING PARTICIPANTS 1,485 adult apnea, as defined by apnea/hypopnea index (AHI) >10 events/hr, were analyzed. 393 who reported using medications on regular basis for more than 6 months. One hundred eighty-three treated "effectively" (i.e. pressure lower 140/90 mm Hg morning evening). Seventy-four "ineffectively," >140/90 or evening. Both groups compared respect clinical demographic data analysis covariance gender, age, body mass (BMI), neck circumference (NC) covariates. INTERVENTIONS MEASUREMENTS AND RESULTS Ineffectively effectively similar age (57 +/- 9) vs. 57 10 years, respectively), had (33.8 7.4 33.4 7.3 kg/m2, respectively). ineffectively significantly higher (44 29 33 25 p<.0005), despite having nocturnal oxygenation (percent total time spent oxygen desaturation 90% was 36 34 30% ineffective effective groups, The difference AHI persisted even after adjusting index. CONCLUSIONS Our results demonstrate that hypertensive whose responds beneficially have less severe those remains elevated therapy. Since neither obesity nor hypoxemia appear be important determinants treatment, suggest resistant hypertension may caused frequent intermittent sympathetic stimulation.