Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

摘要: BACKGROUND: Blood lipid levels as part of the metabolic syndrome are thought to be linked cancer risk. Few epidemiological studies have addressed association between serum triglyceride (STG) concentrations and METHODS: Serum were collected in a health investigation (1988–2003). The analyses included 156153 subjects (71693 men 84460 women), with 5079 incident cancers 4738 women, an average 10.6 years follow-up. All malignancies ascertained from population registry. Multivariate Cox proportional hazard models stratified by age sex used determine adjusted risk estimates 95% confidence interval (95% CI). RESULTS: In women combined, higher STG associated increased lung (4th vs 1st quartile: HR, 1.94; CI, 1.47–2.54), rectal (HR, 1.56; 1.00–2.44), thyroid 1.96; 1.00–3.84). inversely non-Hodgkin’s lymphoma. men, prostate positively renal cancer. gynaecological cancers. Stratification BMI revealed overweight than normal weight women. No other associations found. CONCLUSIONS: Our findings support hypothesis that involved pathogenesis lung, rectal, thyroid, prostate,