Membrane-Bound Conformations of Antimicrobial Agents and Their Modes of Action

摘要: Abstract All antimicrobial agents are inherently membrane active and the complex interactions involved can lead to considerable conformational changes in agents, while also inducing structural rearrangements of lipids. Such modifications trigger series events enabling agent affect integrity microbial or translocate interior cell. Therapeutic use such requires a detailed understanding interaction with bacterial membranes. It is interest note that despite existence diversity chemical compositions many naturally occurring possible number secondary structure conformations they possess, either solution environment, very small number. In spite effort put probe relationship between mode action over past two decades through experiments simulations, same yet be achieved. Furthermore, recent experimental simulation results suggest built-in well-defined as α-helix β-sheet may not essential feature potent but rather ability these acquire amphiphilic conformations, involving spatial separation charged hydrophobic moieties, near membrane. this chapter, we review different have been focus various studies special emphasis on computer simulations their role biomimetic polymers, based methacrylate copolymers,