The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias

摘要: BACKGROUND AND PURPOSE In cardiovascular pharmacology, electrical and mechanical events can be distinguished, the phrase ‘electro-mechanical window’ (EMw) describes temporal difference between these events. We studied whether changes in EMw have potential predictive value for occurrence of arrhythmias fentanyl/etomidate-anaesthetized beagle (FEAB) dogs. EXPERIMENTAL APPROACH The was calculated as differences QT interval QLVPend FEAB dogs during atrial pacing, treatment with isoprenaline or atropine, body temperature induction Torsade de Pointes (TdP) an LQT1 model. KEY RESULTS systole (QT interval) shorter than duration event (QLVPend), providing a positive EMw. Atrial atropine had no major effects on EMw, despite large duration. However, β-adrenoceptor stimulation (with isoprenaline) decreased (from 90 to 5 ms) combination HMR1556, blocker slowly activating potassium current (IKs), induced negative (–109 ms) TdP. Prevention TdP by atenolol verapamil associated less (–23 –16 ms). Mexiletine, poorly effective long treatment, did not affect prevent induction. CONCLUSIONS IMPLICATIONS is marker, other prolongation, risk model. Therefore, we suggest examining marker safety studies biomarker improve clinical management syndrome patients, especially patients borderline prolongation. LINKED ARTICLE This article commented Vargas, pp. 1441–1443 this issue. To view commentary visit http://dx.doi.org/10.1111/j.1476-5381.2010.00980.x