Iminosugar-ferrocene conjugates as potential anticancer agents.
作者： Audrey Hottin , Faustine Dubar , Agata Steenackers , Philippe Delannoy , Christophe Biot
DOI: 10.1039/C2OB25727K
关键词:
摘要: We prepared a series of new iminosugar–ferrocene hybrids displaying potent inhibition fucosidase (bovine kidney) and inactivation MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route brought to light an unprecedented isomerisation 2-ethanalylpyrrolidine.
rsc.org
sci-hub.se 参考文章(34)
Jay J Listinsky, Catherine M Listinsky, Gene P Siegal, The emerging importance of α-L-fucose in human breast cancer: a review American Journal of Translational Research. ,vol. 3, pp. 292- 322 ,(2011)
Ihsan U. Khand, Touhami Lanez, Peter L. Pauson, Ferrocene derivatives. Part 24. Synthesis of dihydro-2-pyrindines and dihydro-3H-2-cyclopent[c]azepines by photolysis of their cyclopentadienyliron derivatives Journal of The Chemical Society-perkin Transactions 1. pp. 2075- 2078 ,(1989) , 10.1039/P19890002075
Juan M. Casas-Solvas, Emilia Ortiz-Salmerón, Juan J. Giménez-Martínez, Luís García-Fuentes, Luís F. Capitán-Vallvey, Francisco Santoyo-González, Antonio Vargas-Berenguel, Ferrocene–Carbohydrate Conjugates as Electrochemical Probes for Molecular Recognition Studies Chemistry: A European Journal. ,vol. 15, pp. 710- 725 ,(2009) , 10.1002/CHEM.200800927
Andreas M. Palmer, Volker Jäger, Preparation and Biological Evaluation of Pyrrolidinediols and Pyrrolidine N-Oxides from D-Ribose Using the Nitrone Approach European Journal of Organic Chemistry. ,vol. 2001, pp. 2547- 2558 ,(2001) , 10.1002/1099-0690(200107)2001:13<2547::AID-EJOC2547>3.0.CO;2-H
Manisha Shah, Shaila Telang, Gira Raval, Pankaj Shah, Prabhudas S. Patel, Serum fucosylation changes in oral cancer and oral precancerous conditions Cancer. ,vol. 113, pp. 336- 346 ,(2008) , 10.1002/CNCR.23556
Dave R. van Staveren, Nils Metzler-Nolte, Bioorganometallic Chemistry of Ferrocene Chemical Reviews. ,vol. 104, pp. 5931- 5955 ,(2004) , 10.1021/CR0101510
Gilles Gasser, Ingo Ott, Nils Metzler-Nolte, None, Organometallic Anticancer Compounds Journal of Medicinal Chemistry. ,vol. 54, pp. 3- 25 ,(2011) , 10.1021/JM100020W
C. Biot, F. Nosten, L. Fraisse, D. Ter-Minassian, J. Khalife, D. Dive, The antimalarial ferroquine: from bench to clinic Parasite. ,vol. 18, pp. 207- 214 ,(2011) , 10.1051/PARASITE/2011183207
Meral Görmen, Pascal Pigeon, Siden Top, Elizabeth A. Hillard, Michel Huché, Christian G. Hartinger, Frédéric de Montigny, Marie-Aude Plamont, Anne Vessières, Gérard Jaouen, Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells ChemMedChem. ,vol. 5, pp. 2039- 2050 ,(2010) , 10.1002/CMDC.201000286
Jean-Bernard Behr, Audrey Erard, Georges Guillerm, A Facile and Rapid Route to a New Series of Pyrrolizidines Structurally Related to (+)‐Alexine and (+)‐Australine European Journal of Organic Chemistry. ,vol. 2002, pp. 1256- 1262 ,(2002) , 10.1002/1099-0690(200204)2002:7<1256::AID-EJOC1256>3.0.CO;2-R