BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5.

作者: Junying Qin , Zhongmei Zhou , Wenlin Chen , Chunyan Wang , Hailin Zhang

DOI: 10.1038/NCOMMS9471

关键词:

摘要: … KLF5 DUBs should stabilize the KLF5 protein and possess oncogenic functions in breast cancer. … results suggest that BAP1 and KLF5 are potential therapeutic targets for breast cancer. …

参考文章(67)
Maria Lelekakis, Jane M. Moseley, T. John Martin, Daphne Hards, Elizabeth Williams, Patricia Ho, Darren Lowen, Jeannie Javni, Fred R. Miller, John Slavin, Robin L. Anderson, A novel orthotopic model of breast cancer metastasis to bone. Clinical & Experimental Metastasis. ,vol. 17, pp. 163- 170 ,(1999) , 10.1023/A:1006689719505
David E Jensen, Monja Proctor, Sandra T Marquis, Heather Perry Gardner, Seung I Ha, Lewis A Chodosh, Alexander M Ishov, Niels Tommerup, Henrik Vissing, Yoshitaka Sekido, John Minna, Anna Borodovsky, David C Schultz, Keith D Wilkinson, Gerd G Maul, Nickolai Barlev, Shelley L Berger, George C Prendergast, Frank J Rauscher, BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression Oncogene. ,vol. 16, pp. 1097- 1112 ,(1998) , 10.1038/SJ.ONC.1201861
Domagoj Vucic, Vishva M. Dixit, Ingrid E. Wertz, Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death Nature Reviews Molecular Cell Biology. ,vol. 12, pp. 439- 452 ,(2011) , 10.1038/NRM3143
Karen H Ventii, Narra S Devi, Kenneth L Friedrich, Tatiana A Chernova, Mourad Tighiouart, Erwin G Van Meir, Keith D Wilkinson, None, BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization Cancer Research. ,vol. 68, pp. 6953- 6962 ,(2008) , 10.1158/0008-5472.CAN-08-0365
Yibin Kang, Peter M. Siegel, Weiping Shu, Maria Drobnjak, Sanna M. Kakonen, Carlos Cordón-Cardo, Theresa A. Guise, Joan Massagué, A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. ,vol. 3, pp. 537- 549 ,(2003) , 10.1016/S1535-6108(03)00132-6
Takeo Nakaya, Seishi Ogawa, Ichiro Manabe, Masami Tanaka, Masashi Sanada, Toshiro Sato, Makoto M. Taketo, Kazuki Nakao, Hans Clevers, Masashi Fukayama, Masahiko Kuroda, Ryozo Nagai, KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer Research. ,vol. 74, pp. 2882- 2891 ,(2014) , 10.1158/0008-5472.CAN-13-2574
A. Dey, D. Seshasayee, R. Noubade, D. M. French, J. Liu, M. S. Chaurushiya, D. S. Kirkpatrick, V. C. Pham, J. R. Lill, C. E. Bakalarski, J. Wu, L. Phu, P. Katavolos, L. M. LaFave, O. Abdel-Wahab, Z. Modrusan, S. Seshagiri, K. Dong, Z. Lin, M. Balazs, R. Suriben, K. Newton, S. Hymowitz, G. Garcia-Manero, F. Martin, R. L. Levine, V. M. Dixit, Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation Science. ,vol. 337, pp. 1541- 1546 ,(2012) , 10.1126/SCIENCE.1221711
Seth J. Goldenberg, Jeffrey L. McDermott, Tauseef R. Butt, Michael R. Mattern, Benjamin Nicholson, Strategies for the Identification of novel inhibitors of deubiquitinating enzymes Biochemical Society Transactions. ,vol. 36, pp. 828- 832 ,(2008) , 10.1042/BST0360828
Sara A Hurvitz, Richard S Finn, What's positive about 'triple-negative' breast cancer? Future Oncology. ,vol. 5, pp. 1015- 1025 ,(2009) , 10.2217/FON.09.68