Subject-Specific Multiscale Modeling to Investigate Effects of Transcranial Magnetic Stimulation

摘要: Objective Transcranial magnetic stimulation (TMS) is an effective intervention in noninvasive neuromodulation used to treat a number of neurophysiological disorders. Predicting the spatial extent which neural tissue affected by TMS remains challenge. The goal this study was develop computational model predict specific locations that are activated during TMS. Using approach, we assessed effects changing coil orientation and waveform. Materials Methods We integrated novel techniques subject-specific model, contains three main components: 1) figure-8 (Magstim, Magstim Company Limited, Carmarthenshire, UK); 2) electromagnetic, time-dependent, nonhomogeneous, finite element whole head; 3) adaptation previously published pyramidal cell neuron model. We then our modeling approach quantify for changes rotation waveform. Results We found shows more detailed predictions than models, underestimate activation. Our results suggest fortuitous sites activation occur all tested orientations. Additionally, show excitability individual elements with ±15°. Conclusions Our indicate widespread previous models suggest. both cortex depend on within ±15° at minimum. Lastly, through means, able provide insight into cellular level, currently unachievable imaging modalities.