Homeobox Gene Deregulation: Impact on the Hallmarks of Cancer.
作者： Dhwani Haria , Honami Naora
DOI: 10.1166/CH.2013.1007
关键词:
摘要: Homeobox genes comprise a super-family of evolutionarily conserved that play essential roles in controlling body plan specification and cell fate determination. Substantial evidence indicates leukemogenesis is driven by abnormal expression homeobox control hematopoiesis. In solid tumors, aberrant has been increasingly found to modulate diverse processes such as proliferation, death, metastasis, angiogenesis DNA repair. This review discusses how are deregulated tumors the functional significance this deregulation hallmarks cancer.
sci-hub.st 参考文章(92)
Yinfei Tan, Mitchell Cheung, Jianming Pei, Craig W. Menges, Andrew K. Godwin, Joseph R. Testa, Upregulation of DLX5 Promotes Ovarian Cancer Cell Proliferation by Enhancing IRS-2-AKT Signaling Cancer Research. ,vol. 70, pp. 9197- 9206 ,(2010) , 10.1158/0008-5472.CAN-10-1568
Xinyan Wu, Hexin Chen, Belinda Parker, Ethel Rubin, Tao Zhu, Ji Shin Lee, Pedram Argani, Saraswati Sukumar, HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition Cancer Research. ,vol. 66, pp. 9527- 9534 ,(2006) , 10.1158/0008-5472.CAN-05-4470
Mark D. Biggin, William McGinnis, Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity. Development. ,vol. 124, pp. 4425- 4433 ,(1997) , 10.1242/DEV.124.22.4425
C. Vandewalle, F. Van Roy, G. Berx, The role of the ZEB family of transcription factors in development and disease Cellular and Molecular Life Sciences. ,vol. 66, pp. 773- 787 ,(2009) , 10.1007/S00018-008-8465-8
D.-L. Qi, T. Ohhira, C. Fujisaki, T. Inoue, T. Ohta, M. Osaki, E. Ohshiro, T. Seko, S. Aoki, M. Oshimura, H. Kugoh, Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. Molecular and Cellular Biology. ,vol. 31, pp. 1624- 1636 ,(2011) , 10.1128/MCB.00470-10
W J Gehring, Y Hiromi, Homeotic Genes and the Homeobox Annual Review of Genetics. ,vol. 20, pp. 147- 173 ,(1986) , 10.1146/ANNUREV.GE.20.120186.001051
A Caré, A Silvani, E Meccia, G Mattia, A Stoppacciaro, G Parmiani, C Peschle, M P Colombo, HOXB7 constitutively activates basic fibroblast growth factor in melanomas. Molecular and Cellular Biology. ,vol. 16, pp. 4842- 4851 ,(1996) , 10.1128/MCB.16.9.4842
Grace Panganiban, John LR Rubenstein, None, Developmental functions of the Distal-less/Dlx homeobox genes Development. ,vol. 129, pp. 4371- 4386 ,(2002) , 10.1242/DEV.129.19.4371
Ricardo D Coletta, Kimberly Christensen, Kelly J Reichenberger, Justin Lamb, Damian Micomonaco, Lili Huang, Douglas M Wolf, Carsten Müller-Tidow, Todd R Golub, Kiyoshi Kawakami, Heide L Ford, The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 6478- 6483 ,(2004) , 10.1073/PNAS.0401139101
Hiroyuki Yoshida, Russell Broaddus, Wenjun Cheng, SuSu Xie, Honami Naora, Deregulation of the HOXA10 Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition Cancer Research. ,vol. 66, pp. 889- 897 ,(2006) , 10.1158/0008-5472.CAN-05-2828