摘要: Interleukin (IL)-1 plays an important role not only in the mediation of inflammation but also destruction cartilage and bone. Together with TNF-alpha it is one most cytokines pathogenesis rheumatoid arthritis (RA) juvenile idiopathic (JIA). The first IL-1 antagonist to be approved for RA was Anakinra, receptor antagonist. Anakinra appears less effective than TNF blockers. Hence, rarely used treatment RA, more IL-1-mediated diseases such as autoinflammatory syndromes, adult-onset Still's disease systemic onset JIA. Two newer antagonists have recently been CAPS (cryopyrin-associated periodic syndromes): Canakinumab, a fully human IL-1beta antibody, rilonacept, fusion protein consisting ligand-binding domain IL-1-receptor accessory protein, bound IgG1. For there proof-of-concept study date canakinumab. There are no prospective data patients who did respond or tolerate antagonists; retrospective analysis, 8% anti-TNF pretreated achieved ACR 20 response.
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